2021.09.17 00:41 Im_Not_Impressed19 Poor u/ultra_penis_man
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2021.09.17 00:41 Kingle0813 Madara is a Real N****
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2021.09.17 00:41 Rude-Floor103 Anything on this girl from Brownsville?
|submitted by Rude-Floor103 to 956instathots [link] [comments]|
2021.09.17 00:41 but_why77 To the little kids who were never given a fair chance,
I know the burning physical sensational pain you've felt running down your chest. The one you've question if others have felt, especially the ones who have hurt you. This one's for the kids who were praised for being "so mature" for their age, "so strong", "so calm", "so fair", "so resilient". You were told you were strong because of everything you've been through. Well I'm here to tell you that we would have been even stronger if we were given a fair chance early in life. Those who have hurt us do not get the credit of making us stronger. We were strong from the very damn beginning. Despite how many times we've felt unaccepted and misunderstood by those who claim to accept and understand us. Despite how many times we've felt frustrated. Despite how many times we've tried to explain ourselves to those who love us. Despite how many times we've wanted to scream, but instead chose patience and calmness.
As someone who is still figuring things out day-by-day myself, i wanted to let you know that I see you and I hear you. We don't always have to have it together for the sake of others. It's okay to have setbacks and to fall apart. We've been fighting our whole lives and it's time we allow ourselves to be human; it's time we stop catering to the needs of others, because truth is... it's fucking exhausting. Those who love you will understand. I will understand. Those who won't are not your problem.
There are many supportive articles i have come across, but the article below is the one that truly feels like it hits home for me. I still read and come back to this article when i feel like no one truly understands me; personally, when i feel helpless reassuring my SO's insecurities about my dating history, all which im still trying to accept has close connections with my childhood. This article makes me cry every time, but that's just how effective it is. So i want to share it with you and i hope it helps you the way that it helps me. I see you and I love you. Remember to take care of yourself.
submitted by but_why77 to UnsentLetters [link] [comments]
2021.09.17 00:41 KeraKolrad TOP3 SVAIGINIMOSI PRIEMONĖS
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2021.09.17 00:41 GlenD92 Ragnar Lothbrok done today by my good friend in London, UK. https://instagram.com/tattoohaydn?utm_medium=copy_link
|submitted by GlenD92 to tattoos [link] [comments]|
2021.09.17 00:41 papabakersere update is bangin’
2021.09.17 00:41 r3ckon3r On "non-department store" brands
Relatively new to fragrances. I have experience with the department store brands (YSL/DG/maybe Le Labo?) - but beyond that what are some other brands that are worth seeking out? I'm curious what kind of brands enthusiasts are really into (whether its up and comers, current hype, classic brands, etc.). Or is this distinction not really a thing, and the "department store" category is actually an unfair characterization? Really just looking to learn more about the brand landscape. Thanks!
submitted by r3ckon3r to fragrance [link] [comments]
2021.09.17 00:41 RLCD-Bot [Grey Paladin] [Grey Paladin: ShapeRacer] [Glitch] [Grey Morrowhatch]
|submitted by RLCD-Bot to RLCustomDesigns [link] [comments]|
2021.09.17 00:41 dem0n0cracy Paternal ketogenic diet in mice programmes offspring fasting metabolism and physical activity -- Keto-pups were more active during fasting, and showed serum and liver histology changes suggesting better adaptation to prolonged fasting.
SO 02 Diabetes across generations https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8408311/
Paternal ketogenic diet in mice programmes offspring fasting metabolism and physical activity
J. Magrill1, M. Stolovich-Rain1, E. Ben Cnaan2, S. Baraghithy2, B. Glaser3, Y. Tam2, Y. Dor1;
1Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University of Jerusalem, Jerusalem, 2Obesity and Metabolism Laboratory, The Institute for Drug Research, School of Pharmacy, Faculty of M, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem, 3Hadassah Medical Center, Department of Endocrinology, Hebrew University of Jerusalem, Jerusalem, Israel.
Background and aims: Pre-conceptional paternal life experience has been proposed to be an important determinant of offspring metabolic health, including predisposition to metabolic syndrome, cardiovascular disease and diabetes. However, the evolutionary and physiological relevance of such phenomena and the underlying molecular mechanisms remain unclear. In this study we aimed to assess paternal inheritance of metabolic traits following a sustained elevation in circulating ketones, small-chain energy metabolites with epigenetic signalling properties.
Materials and methods: We induced a consistent, sustained 4-fold increase in circulating blood ketones in 4-week old male CD-1 mice, for a 4-week period (the duration of sperm formation in mice) by ad-libitum feeding of a ketogenic diet, with control males fed normal chow. Males fed ketogenic diet did not show significant differences in body-weight or blood glucose levels compared with chow-fed mice. Males were mated for with females fed normal chow and then removed from the cage. Resulting litters were standardized at birth to 8 pups. Male offspring were weaned at 3.5 weeks, weight-matched, monitored throughout life for metabolic differences, and sacrificed at 45 weeks.
Results: Male keto-pups (offspring from ketogenic fathers) showed transient glucose intolerance and a transient reduction in insulin sensitivity that were resolved by 42 weeks, compared with male control-pups. During a 48-hour fasting at 45 weeks, keto-pups were more active (voluntary wheel-running), and had a higher respiratory quotient as measured by metabolic cages. After the 48-hour fast, sacrificed keto-pups show elevated fat content in liver (30% vs. 19%, by Oil Red O staining), and elevated serum HDL, cholesterol and ketones. Transcriptome analysis of keto-pup livers suggested significant differences in circadian rhythm gene expression patterns.
Conclusion: We report here the impact of a paternal ketogenic diet on offspring fasting metabolism and physical activity. Keto-pups were more active during fasting, and showed serum and liver histology changes suggesting better adaptation to prolonged fasting. Transcriptome analysis suggests that the effects involve alteration to the circadian clock, shown previously to be profoundly affected by ketogenic diet (but not shown before in progeny of mice fed a ketogenic diet). We speculate that paternal starvation, via elevated ketone levels, programs the offspring for better coping with life-threatening starvation. The molecular mechanisms underlying paternal transmission in this setting remain to be elucidated, as are the implications for modern humans exercising a ketogenic diet.
Disclosure: J. Magrill: None.
submitted by dem0n0cracy to ketoscience [link] [comments]
2021.09.17 00:41 WolfieTheFolf Loading stuck at 0% preloaded
Hi i need help, i tried loading into solo and normal zombies (all modes) and they are getting stuck at 0%preloaded, any way to fix this?
I've tried deleting and redownloading, tried going onto multiplayer bots still doesnt work, nothing works :(
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2021.09.17 00:41 SinisterGenocide Steel series duo
Hey guys I purchased a steel series duo controller to use with the steam link app to play some games while I'm not home. The app says specifically that any Bluetooth controller compatible with my device will work.
It connected and shows in the steam link app but will not actually work. None of the buttons work while in the app.
Does anyone know what I'm dojng wrong?
submitted by SinisterGenocide to Steam_Link [link] [comments]
2021.09.17 00:41 Ok_Independence_1832 Jessica Beppler
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2021.09.17 00:41 AbsurdPiccard Licenses and toasters
2021.09.17 00:41 Skeletampire Sand VS Sand (and the many reactions towards Kukri)
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2021.09.17 00:41 essaycode CSCI567 Homework #5……solved
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2021.09.17 00:41 charmilliona1re SafeEarn Featured in a Yahoo Finance Article:
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2021.09.17 00:41 d6u4 What's an example of ageism that you've experienced in the workplace?
It was my birthday recently and I was asked how old I turned, when I told them, a lot of them thought I was older than I am. I'm somewhat new to this job and now I don't get the same respect knowing that I'm almost 15 years younger than they thought I was.
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2021.09.17 00:41 limitless4104 Sleepy toes 🤤
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2021.09.17 00:41 ineedtoloseweight123 Those poor people...
|submitted by ineedtoloseweight123 to Draven [link] [comments]|
2021.09.17 00:41 SolanaPandas Solana Cute Pandas! https://discord.gg/x89Z3nYa Adopt one soon!
| Solana Cute Pandas and the Metajungle: Become a Panda Parent today|
🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼
Hey fam! Solana Cute Pandas is a project that we've been really passionate about. All the pandas on Solana currently are too aggressive and don't fit in with the kind cuddly nature of the pandas.
Website: Coming Soon
MINTING on 9/23/21 at 11:59PM UTC.
COUNT? 4040 unique generative cute and cuddly NFTs. Pandas are dangerously endangered and it's critical that they get the support they need in the world.
Long-term vision: Our longer-term vision is to have an online community wherein various cities around the world owners of the mint that participate in our discord are invited to parties where they can meet their fellow Panda Parents.
We love Pandas so much and we want you to as well!
🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼 🐼
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2021.09.17 00:41 CiggyButt RSK with music - Mixcloud
I thought I would share my mixcloud account which has a playlist of the XFM show (only series 1 - 3) and the Radio 2 christmas special with the original music.
I've seen there were some recently there has been some issues surrounding the podcasts on Spotify.
I have a backup of the podcast
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2021.09.17 00:41 HumidHarold12420 How ethnically diverse was the city/town you grew up in?
2021.09.17 00:41 Goneisthedead Sarah Palin: Biden 'gets everything wrong'
|submitted by Goneisthedead to walkaway [link] [comments]|
2021.09.17 00:41 AstralIndigo92 What is the wackiest or non-orthodox team that you used on auto for timeline that got you at least 75% win rate for a week?
This week I used Wasp, Knull, Colossus on auto in Vibranium and got a 53 win 17 loss streak (75.71%). Though, I think the team would have fared better if I used Knull, Colossus and Ebony Maw. I have a Mighty Steel CTP of Authority on Knull, 94% Max HP on equipped comic cards, and 6% pierce.
After reset, would be curious to try to out Wenwu, Thanos, Hulk team for a week.
In case anyone is curious, my IGN is Taukens.
What are some wackiest or non-orthodox teams that you have tried that still got you a decent win rate in timeline?
submitted by AstralIndigo92 to future_fight [link] [comments]